材料科学
微尺度化学
纳米纤维
纺纱
人造皮肤
再生(生物学)
生物医学工程
生物相容性
纳米技术
伤口愈合
软机器人
复合材料
计算机科学
医学
外科
人工智能
机器人
数学教育
数学
细胞生物学
冶金
生物
作者
Yue Dong,Zhiyu Ding,Yuting Bai,Ling‐Yu Lu,Ting Dong,Qing Li,Ji‐Dong Liu,Su Chen
标识
DOI:10.1002/advs.202404433
摘要
Abstract Growing demand for wound care resulting from the increasing chronic diseases and trauma brings intense pressure to global medical health service system. Artificial skin provides mechanical and microenvironmental support for wound, which is crucial in wound healing and tissue regeneration. However, challenges still remain in the clinical application of artificial skin since the lack of the synergy effect of necessary performance. In this study, a multi‐functional artificial skin is fabricated through microfluidic spinning technology by using core‐shell gel nanofiber scaffolds (NFSs). This strategy can precisely manipulate the microstructure of artificial skin under microscale. The as‐prepared artificial skin demonstrates superior characteristics including surface wettability, breathability, high mechanical strength, strain sensitivity, biocompatibility and biodegradability. Notably, this artificial skin has the capability to deliver medications in a controlled and sustained manner, thereby accelerating the wound healing process. This innovative approach paves the way for the development of a new generation of artificial skin and introduces a novel concept for the structural design of the unique core‐shell gel NFSs.
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