Genetic and Epigenetic Regulation of Cortactin (CTTN) by Inflammatory Factors and Mechanical Stress in Human Lung Endothelial Cells

Cortactin, an actin-binding cytoskeletal protein, plays a crucial role in maintaining endothelial cell (EC) barrier integrity and regulating vascular permeability. The gene encoding cortactin, CTTN, is implicated in various lung inflammatory disorders. Despite this, the transcriptional regulation of CTTN by inflammatory stimuli and promoter SNPs remains unexplored.