再生(生物学)
自愈水凝胶
伤口愈合
对偶(语法数字)
双重角色
化学
细胞生物学
医学
外科
生物
高分子化学
组合化学
艺术
文学类
作者
Yisheng Gao,Long Yin,Jianye Zhang,Miao Zhang,Wanhua Li,Yumin Yang,Yahong Zhao
出处
期刊:ACS materials letters
[American Chemical Society]
日期:2024-08-20
卷期号:: 4312-4322
标识
DOI:10.1021/acsmaterialslett.4c01265
摘要
Wound healing, a complex process involving hemostasis, inflammation, proliferation, and remodeling, is often hindered by factors like infection or a weakened immune response. Existing studies often neglect the crucial role of nerve regeneration. Our study introduces a novel hydrogel system using functionalized bisphosphonic acid grafted onto sodium alginate, combined with hyaluronic acid and metal ions (Fe3+ and Zn2+), to enhance wound healing in infectious environments. The interaction between bisphosphonates and Zn2+ forms a secondary network that facilitates the release of Fe3+ and Zn2+ ions. This mechanism offers broad-spectrum antibacterial action and regulates the immune environment, promoting M2 macrophage polarization. Additionally, the hydrogel supports neurogenesis and angiogenesis, essential for complete tissue repair. Enhancing nerve regeneration restores neural function and accelerates wound healing. Its injectability, self-healing properties, and biocompatibility make this hydrogel a promising candidate for advanced wound dressings, potentially reducing healing time and improving infected wound management.
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