尼安德特人
基因流
进化生物学
生物
古代DNA
人类进化
基因组
人口
人类基因组
遗传学
基因
遗传变异
地理
考古
医学
环境卫生
作者
Liming Li,Troy J. Comi,Rob Bierman,Joshua M. Akey
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-07-11
卷期号:385 (6705)
被引量:7
标识
DOI:10.1126/science.adi1768
摘要
Although it is well known that the ancestors of modern humans and Neanderthals admixed, the effects of gene flow on the Neanderthal genome are not well understood. We develop methods to estimate the amount of human-introgressed sequences in Neanderthals and apply it to whole-genome sequence data from 2000 modern humans and three Neanderthals. We estimate that Neanderthals have 2.5 to 3.7% human ancestry, and we leverage human-introgressed sequences in Neanderthals to revise estimates of Neanderthal ancestry in modern humans, show that Neanderthal population sizes were significantly smaller than previously estimated, and identify two distinct waves of modern human gene flow into Neanderthals. Our data provide insights into the genetic legacy of recurrent gene flow between modern humans and Neanderthals.
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