Incorporation of estimated glomerular filtration rate into the GRACE score improves its prognostic performance for 10-year outcome prediction in non-ST segment elevation acute coronary syndrome treated with percutaneous coronary intervention

Current guidelines for the management of patients with non-ST elevation acute coronary syndrome (NSTE-ACS) recommend the Global Registry of Acute Coronary Events (GRACE) score for risk stratification.1,2 Among the variables used in the score, serum creatinine (sCr) accounts for the prognostic impact of chronic kidney disease (CKD) in this setting.3 However, estimated glomerular filtration rate (eGFR) is known to be a better measure of renal function than sCr. We developed two modified GRACE scores incorporating eGFR, as derived by two clinically validated formulas, and compared their long-term prognostic performance to that of the standard GRACE in a population of patients with NSTE-ACS.