谷胱甘肽
细胞生物学
信号转导
化学
细胞凋亡
p38丝裂原活化蛋白激酶
癌症研究
机制（生物学）
活性氧
磷酸化
生物
蛋白激酶A
生物化学
酶
认识论
哲学
作者
Ying Zhang,Qianyu Zhang,Zheng Chu,Lin Chen,Jiayun Chen,Yang Yang,Huan Tang,Guangqing Cheng,Ang Ma,Ying Zhang,Chen Wang,Peng Gao,Fei Xia,Qiuyan Guo,Qiaoli Shi,Guang Han,Jigang Wang,Yinhua Zhu
摘要
We have identified oridonin as a novel senolytic and revealed the mechanism of oridonin by covalently inhibiting a class of glutathione S-transferases (GSTs) to increase the ROS level, and activate p38 to induce apoptosis in senescent cells.
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