Mechanical thrombectomy in acute basilar artery stroke: a systematic review and Meta-analysis of randomized controlled trials

医学 荟萃分析 随机对照试验 相对风险 冲程(发动机) 基底动脉 内科学 置信区间 神经外科 神经学 外科 机械工程 精神科 工程类
作者
Abid Malik,Brian Drumm,Lucio D’Anna,Isabelle Brooks,Benjamin Low,Oishik Raha,Khawar Shabbir,Orsolya Vittay,Joseph Kwan,Zoe Brown,Omid Halse,Sohaa Jamil,Dheeraj Kalladka,Marius Venter,Harri Jenkins,Neil Rane,Abhinav Singh,Maneesh C. Patel,Charles Hall,Gavin Fatania,Dylan Roi,Kyriakos Lobotesis,Soma Banerjee
出处
期刊:BMC Neurology [BioMed Central]
卷期号:22 (1) 被引量:7
标识
DOI:10.1186/s12883-022-02953-2
摘要

Abstract Background The evidence for mechanical thrombectomy in acute basilar artery occlusion has until now remained inconclusive with basilar artery strokes associated with high rates of death and disability. This systematic review and meta-analysis will summarize the available evidence for the effectiveness of mechanical thrombectomy in acute basilar artery occlusion compared to best medical therapy. Methods We conducted a systematic review and meta-analysis of randomized controlled trials using Embase, Medline and the Cochrane Central Register of Controlled Trials (CENTRAL). We calculated risk ratios (RRs) and 95% confidence intervals (CIs) to summarize the effect estimates for each outcome. Results We performed a random effects (Mantel-Haenszel) meta-analysis of the four included randomized controlled trials comprising a total of 988 participants. We found a statistically significant improvement in the rates of those with a good functional outcome (mRS 0–3, RR 1.54, 1.16–2.06, p = 0.003) and functional independence (mRS 0–2, RR 1.69, 1.05–2.71, p = 0.03) in those who were treated with thrombectomy when compared to best medical therapy alone. Thrombectomy was associated with a higher level of sICH (RR 7.12, 2.16–23.54, p = 0.001) but this was not reflected in a higher mortality rate, conversely the mortality rate was significantly lower in the intervention group (RR 0.76, 0.65–0.89, p = 0.0004). Conclusions Our meta-analysis of the recently presented randomized controlled studies is the first to confirm the disability and mortality benefit of mechanical thrombectomy in basilar artery stroke.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
发文章发布了新的文献求助10
1秒前
赘婿应助学术奴才采纳,获得10
1秒前
土亢土亢土完成签到,获得积分0
2秒前
2秒前
yoneyamai发布了新的文献求助10
4秒前
大个应助慕容雅柏采纳,获得10
4秒前
幸福的雪枫完成签到,获得积分10
5秒前
外向的忆霜完成签到,获得积分10
5秒前
fighting发布了新的文献求助10
5秒前
smm完成签到 ,获得积分10
5秒前
Tao完成签到,获得积分10
6秒前
缓慢的开山完成签到 ,获得积分10
7秒前
笑点低的咖啡完成签到,获得积分10
7秒前
7秒前
细腻亦巧发布了新的文献求助10
7秒前
zm完成签到,获得积分10
8秒前
9秒前
9秒前
不懂科研的小徐完成签到,获得积分10
10秒前
11秒前
大模型应助twob采纳,获得10
11秒前
11秒前
你的女孩TT完成签到,获得积分10
11秒前
11秒前
12秒前
昏睡的蟠桃应助合适夏天采纳,获得200
13秒前
yuanyuan完成签到,获得积分10
14秒前
15秒前
15秒前
在水一方应助积极的邪欢采纳,获得10
15秒前
慕容雅柏发布了新的文献求助10
15秒前
lasdklas发布了新的文献求助10
16秒前
天天完成签到 ,获得积分10
16秒前
vc小星完成签到,获得积分10
17秒前
icerain发布了新的文献求助10
17秒前
17秒前
17秒前
吃猫的鱼发布了新的文献求助10
18秒前
Akim应助Lily采纳,获得10
18秒前
19秒前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 588
T/CIET 1202-2025 可吸收再生氧化纤维素止血材料 500
Interpretation of Mass Spectra, Fourth Edition 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3951800
求助须知:如何正确求助?哪些是违规求助? 3497233
关于积分的说明 11086336
捐赠科研通 3227767
什么是DOI,文献DOI怎么找? 1784520
邀请新用户注册赠送积分活动 868692
科研通“疑难数据库(出版商)”最低求助积分说明 801163