痴呆
队列
危险系数
微粒
人口
环境科学
环境化学
化学
医学
环境卫生
疾病
置信区间
内科学
有机化学
作者
Liuhua Shi,Qiao Zhu,Yifan Wang,Hua Hao,Haisu Zhang,Joel Schwartz,Heresh Amini,Aaron van Donkelaar,Randall V. Martin,Kyle Steenland,Jeremy A. Sarnat,W. Michael Caudle,Tszshan Ma,Haomin Li,Howard H. Chang,Jeremiah Z Liu,Thomas S. Wingo,Xiaobo Mao,Armistead G. Russell,R. J. Weber,Pengfei Liu
标识
DOI:10.1073/pnas.2211282119
摘要
Growing evidence suggests that fine particulate matter (PM 2.5 ) likely increases the risks of dementia, yet little is known about the relative contributions of different constituents. Here, we conducted a nationwide population-based cohort study (2000 to 2017) by integrating the Medicare Chronic Conditions Warehouse database and two independently sourced datasets of high-resolution PM 2.5 major chemical composition, including black carbon (BC), organic matter (OM), nitrate (NO 3 − ), sulfate (SO 4 2− ), ammonium (NH 4 + ), and soil dust (DUST). To investigate the impact of long-term exposure to PM 2.5 constituents on incident all-cause dementia and Alzheimer’s disease (AD), hazard ratios for dementia and AD were estimated using Cox proportional hazards models, and penalized splines were used to evaluate potential nonlinear concentration–response (C-R) relationships. Results using two exposure datasets consistently indicated higher rates of incident dementia and AD for an increased exposure to PM 2.5 and its major constituents. An interquartile range increase in PM 2.5 mass was associated with a 6 to 7% increase in dementia incidence and a 9% increase in AD incidence. For different PM 2.5 constituents, associations remained significant for BC, OM, SO 4 2− , and NH 4 + for both end points (even after adjustments of other constituents), among which BC and SO 4 2− showed the strongest associations. All constituents had largely linear C-R relationships in the low exposure range, but most tailed off at higher exposure concentrations. Our findings suggest that long-term exposure to PM 2.5 is significantly associated with higher rates of incident dementia and AD and that SO 4 2− , BC, and OM related to traffic and fossil fuel combustion might drive the observed associations.
科研通智能强力驱动
Strongly Powered by AbleSci AI