γ-Glutamyltransferase and cancer risk: The Korean cancer prevention study

医学 内科学 癌症 危险系数 胃肠病学 结直肠癌 体质指数 肝癌 置信区间 胃癌 肺癌 比例危险模型 入射(几何) 物理 光学
作者
Yejin Mok,Dongkoog Son,Young Duk Yun,Sun Ha Jee,Jonathan M. Samet
出处
期刊:International Journal of Cancer [Wiley]
卷期号:138 (2): 311-319 被引量:48
标识
DOI:10.1002/ijc.29659
摘要

Elevated serum γ-glutamyltransferase (GGT) is a marker of hepatic injury and is associated with risk of chronic disease. However, the value of GGT as a biomarker for cancer risk remains unclear. Therefore, we evaluated the association of serum GGT with cancer incidence among more than 1.6 million Koreans. We included 1,662,087 Koreans (1,108,121 men and 553,966 women aged 20-95 years) who received health insurance from the National Health Insurance Service and had a biennial medical evaluation between 1995 and 1998. Follow-up was through December 2012. Using Cox proportional hazards models, we adjusted for age, smoking status, alcohol consumption, exercise and body mass index after exclusion of early cases (cancer diagnosis or death within 5 years of starting follow-up) and estimated hazard ratios (HRs) of overall and organ-specific cancer incidence by GGT quintiles. During the 17-year follow-up, 129,087 new cancer cases occurred among the participants. Across levels of GGT, there was a positive gradient of HR and the highest quintile of GGT (≥ 60 IU/L) had the highest HR for all cancers in both men and women. By cancer site, the association was strongest for liver cancer, comparing the highest and lowest strata in men [HR, 6.67; 95% confidence interval (95%CI), 5.88-7.57] and in women (HR, 7.57; 95%CI, 6.41-8.94). Significant associations were also observed for cancers of the esophagus, larynx, stomach, colorectal, bile duct and lung in men and of the bile duct in women. Increased serum GGT level is independently associated with risk of cancer.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
乔安发布了新的文献求助10
刚刚
炫哥IRIS发布了新的文献求助10
刚刚
LaTeXer给积极行天的求助进行了留言
1秒前
ww发布了新的文献求助10
1秒前
Carlo完成签到,获得积分10
2秒前
蓝胖子完成签到 ,获得积分10
3秒前
4秒前
终生科研徒刑完成签到 ,获得积分10
4秒前
5秒前
ysc发布了新的文献求助20
7秒前
8秒前
LKX完成签到 ,获得积分10
8秒前
纯真的诗兰完成签到,获得积分10
9秒前
自然函完成签到 ,获得积分10
9秒前
等一个晴天完成签到,获得积分10
10秒前
as发布了新的文献求助100
10秒前
天天快乐应助科研通管家采纳,获得10
10秒前
研友_VZG7GZ应助科研通管家采纳,获得10
10秒前
个性元枫应助科研通管家采纳,获得10
10秒前
kingwill应助科研通管家采纳,获得20
10秒前
顾矜应助科研通管家采纳,获得10
10秒前
10秒前
慕青应助科研通管家采纳,获得10
10秒前
今后应助科研通管家采纳,获得10
10秒前
隐形曼青应助科研通管家采纳,获得10
10秒前
Hello应助科研通管家采纳,获得10
10秒前
小蘑菇应助科研通管家采纳,获得10
10秒前
Ava应助科研通管家采纳,获得10
11秒前
海东来应助科研通管家采纳,获得30
11秒前
JamesPei应助科研通管家采纳,获得10
11秒前
个性元枫应助科研通管家采纳,获得10
11秒前
茕凡桃七完成签到,获得积分10
11秒前
大个应助科研通管家采纳,获得10
11秒前
所所应助科研通管家采纳,获得10
11秒前
Hello应助科研通管家采纳,获得30
11秒前
11秒前
烟花应助科研通管家采纳,获得10
12秒前
12秒前
12秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038446
求助须知:如何正确求助?哪些是违规求助? 3576149
关于积分的说明 11374627
捐赠科研通 3305875
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892680
科研通“疑难数据库(出版商)”最低求助积分说明 815048