阻塞性睡眠呼吸暂停
肠道菌群
失调
丁酸盐
血压
医学
内科学
内分泌学
粪便
微生物群
生理学
生物
免疫学
生物信息学
食品科学
微生物学
发酵
作者
David J. Durgan,Bhanu Priya Ganesh,Julia Cope,Nadim J. Ajami,Sharon C. Phillips,Joseph F. Petrosino,Emily B. Hollister,Robert M. Bryan
出处
期刊:Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:2016-02-01
卷期号:67 (2): 469-474
被引量:253
标识
DOI:10.1161/hypertensionaha.115.06672
摘要
Individuals suffering from obstructive sleep apnea (OSA) are at increased risk for systemic hypertension. The importance of a healthy gut microbiota, and detriment of a dysbiotic microbiota, on host physiology is becoming increasingly evident. We tested the hypothesis that gut dysbiosis contributes to hypertension observed with OSA. OSA was modeled in rats by inflating a tracheal balloon during the sleep cycle (10-s inflations, 60 per hour). On normal chow diet, OSA had no effect on blood pressure; however, in rats fed a high-fat diet, blood pressure increased 24 and 29 mm Hg after 7 and 14 days of OSA, respectively ( P <0.05 each). Bacterial community characterization was performed on fecal pellets isolated before and after 14 days of OSA in chow and high-fat fed rats. High-fat diet and OSA led to significant alterations of the gut microbiota, including decreases in bacterial taxa known to produce the short chain fatty acid butyrate ( P <0.05). Finally, transplant of dysbiotic cecal contents from hypertensive OSA rats on high-fat diet into OSA recipient rats on normal chow diet (shown to be normotensive) resulted in hypertension similar to that of the donor (increased 14 and 32 mm Hg after 7 and 14 days of OSA, respectively; P <0.05). These studies demonstrate a causal relationship between gut dysbiosis and hypertension, and suggest that manipulation of the microbiota may be a viable treatment for OSA-induced, and possibly other forms of, hypertension.
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