Effects of Atorvastatin on Early Recurrent Ischemic Events in Acute Coronary Syndromes<SUBTITLE>The MIRACL Study: A Randomized Controlled Trial</SUBTITLE>

Reduction with Aggressive Cholesterol Lowering (MIRACL) Study Investigators B2][3] Previous trials excluded patients who had experienced recent unstable angina or acute myocardial infarction (MI).However, it is within the early period after an acute coronary syndrome (ACS) that patients experience the highest rate of death and recurrent ischemic events. 4,5o date, it has not been determined whether initiation of treatment with a statin soon after an ACS can reduce the occurrence of these early events.Recent studies indicate that statins have salutary physiologic effects within weeks.In conjunction with lowering total and low-density lipoprotein (LDL) cholesterol, statins may improve endo-