Characteristics of Anteriorly Located Prostate Cancer and the Usefulness of Multiparametric Magnetic Resonance Imaging for Diagnosis

No AccessJournal of UrologyAdult Urology1 Aug 2016Characteristics of Anteriorly Located Prostate Cancer and the Usefulness of Multiparametric Magnetic Resonance Imaging for Diagnosis Myong Kim, Seung-Kwon Choi, Myungchan Park, Myungsun Shim, Cheryn Song, In Gab Jeong, Jun Hyuk Hong, Choung-Soo Kim, and Hanjong Ahn Myong KimMyong Kim , Seung-Kwon ChoiSeung-Kwon Choi , Myungchan ParkMyungchan Park , Myungsun ShimMyungsun Shim , Cheryn SongCheryn Song , In Gab JeongIn Gab Jeong , Jun Hyuk HongJun Hyuk Hong , Choung-Soo KimChoung-Soo Kim , and Hanjong AhnHanjong Ahn View All Author Informationhttps://doi.org/10.1016/j.juro.2016.03.075AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We analyzed the pathological and oncologic characteristics of anteriorly located prostate cancer and assessed the usefulness of magnetic resonance imaging to detect anterior prostate cancer. Materials and Methods: We analyzed the records of 728 consecutive patients treated with radical prostatectomy. Patients were categorized with anterior or prostate cancer or tumors involving the anterior and posterior prostate according to the dominant tumor location on whole mount section. Results: The anterior and posterior prostate cancer groups and the group with cancer at both locations represented 31.0%, 46.7% and 22.3% of the total number of patients, respectively. Anterior prostate cancer was less commonly palpable (p <0.001) and needed more frequent repeat biopsy (p = 0.012) than posterior prostate cancer. Moreover, the anterior group had fewer positive cores than the posterior group (p <0.001) despite comparable tumor volumes. Gleason score upgrading was more frequently observed in anterior than in posterior prostate cancer (p = 0.003). However, final pathological features did not significantly differ. Only the seminal vesicle involvement rate was lower in anterior than in posterior prostate cancer (p <0.001). Estimated 5-year biochemical recurrence-free survival in patients with anterior prostate cancer was 87.5%, significantly higher than in patients with posterior prostate cancer (77.4%, p = 0.001) and patients with anterior plus posterior involvement (74.4%, p <0.001). Multivariate analysis revealed that anterior location was an independent prognostic factor for biochemical recurrence (HR 0.403) along with other well-known prognostic factors. To detect anterior prostate tumors the sensitivity and specificity of magnetic resonance imaging were 78.1% and 58.2%, respectively. Conclusions: Anterior prostate cancer had pathological features and favorable oncologic outcomes comparable to those of posterior prostate cancer but also more frequent Gleason score upgrading. Magnetic resonance imaging had moderate diagnostic performance for detecting lesions in the anterior prostate. 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Google Scholar © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byTruong M, Weinberg E, Hollenberg G, Borch M, Park J, Gantz J, Feng C, Frye T, Ghazi A, Wu G, Joseph J, Rashid H and Messing E (2018) Institutional Learning Curve Associated with Implementation of a Magnetic Resonance/Transrectal Ultrasound Fusion Biopsy Program Using PI-RADS™ Version 2: Factors that Influence SuccessUrology Practice, VOL. 5, NO. 1, (69-75), Online publication date: 1-Jan-2018.Jeong I, Yoo S, Lee C, Kim M, You D, Song C, Park S, Hong J, Ahn H and Kim C (2018) Obesity as a Risk Factor for Unfavorable Disease in Men with Low Risk Prostate Cancer and its Relationship with Anatomical Location of TumorJournal of Urology, VOL. 198, NO. 1, (71-78), Online publication date: 1-Jul-2017. Volume 196Issue 2August 2016Page: 367-373Supplementary Materials Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.Keywordsdiagnostic imagingprostatic neoplasmsmagnetic resonance imagingprognosisneoplasm recurrence, localMetricsAuthor Information Myong Kim More articles by this author Seung-Kwon Choi More articles by this author Myungchan Park More articles by this author Myungsun Shim More articles by this author Cheryn Song More articles by this author In Gab Jeong More articles by this author Jun Hyuk Hong More articles by this author Choung-Soo Kim More articles by this author Hanjong Ahn More articles by this author Expand All Advertisement PDF downloadLoading ...