Cellulose nanocrystals extracted from rice husks as a reinforcing material in gelatin hydrogels for use in controlled drug delivery systems

明胶 结晶度 自愈水凝胶 肿胀 的 药物输送 控制释放 化学工程 化学 材料科学 动态力学分析 高分子化学 复合材料 有机化学 聚合物 纳米技术 工程类
作者
Shok Yin Ooi,Ishak Ahmad,Mohd Cairul Iqbal Mohd Amin
出处
期刊:Industrial Crops and Products [Elsevier BV]
卷期号:93: 227-234 被引量:227
标识
DOI:10.1016/j.indcrop.2015.11.082
摘要

Hydrogels with remarkable sensitivity toward changes in pH were prepared using gelatin reinforced with cellulose nanocrystals (CNCs). Glutaraldehyde was used as a crosslinker because of its high chemical reactivity toward the NH2 group on gelatin. CNC ratios of 0%, 5%, 10%, 15%, 20%, and 25% were chosen to study the effects of CNCs on the dynamic mechanical properties and swelling behavior of gelatin-based hydrogels. Crosslinking between gelatin monomers was confirmed by the presence of a CN stretching group at 1630 cm−1 in the FTIR spectrum of gelatin hydrogels. The overall crystallinity and dynamic mechanical properties of gelatin hydrogels increased as the CNC content increased. The increase in the overall crystallinity improved the storage modulus of the CNC-gelatin hydrogel from 122 Pa to 468 Pa by the addition of 25% CNC. From the swelling test, CNC-gelatin hydrogels showed excellent pH sensitivity with a maximum swelling ratio at pH 3. The ability of the CNC-gelatin hydrogel to respond to different pH values along with its high dynamic mechanical stability suggested that CNC-gelatin hydrogels are promising candidates as drug carriers. Theophylline was used in this research as a model drug to further evaluate the potential of these CNC-gelatin hydrogels to act as drug carriers. Drug loading efficiency and drug release profiles of the CNC-gelatin hydrogels were studied. The findings suggest that gelatin hydrogels reinforced with 15% CNC are the best potential candidates for controlled drug delivery system.
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