Recent Development of Recoverable MacMillan Catalyst in Asymmetric Organic Transformations

Abstract Chiral imidazolidinone as an organocatalyst was developed by MacMillan and co‐workers in 2000 and they evaluated this organocatalyst originally in the enantioselective Diels‐Alder reaction. Later, this catalyst was used in a number of other asymmetric organic transformations. Chiral organocatalysts are expensive, therefore their recoverability and reusability are highly desirable to make the organic transformation economically viable for industrial application. Hence, the chiral imidazolidinone was modified and attached to different supports for its recoverability and reusability. A number of recoverable imidazolidinones have been reported in asymmetric Diels‐Alder reactions. In this review, we have summarized the reports on reusable and recoverable imidazolidinones (MacMillan catalysts) as organocatalysts in asymmetric organic transformations. magnified image