发病机制
病理
神经丝
免疫组织化学
组织病理学
无症状的
免疫染色
CD8型
病变
医学
生物
解剖
免疫系统
免疫学
作者
Kaiyun Yang,Kesava Reddy,Bill Wang,Aleksa Cenic,John Provias,Snežana Popović,William H. Yong,Michel W. Bojanowski,Robert Hammond,Jian‐Qiang Lu
摘要
ABSTRACT: Background: Calcifying pseudoneoplasm of the neuraxis (CAPNON) is a rare tumor-like lesion with unknown pathogenesis. It is likely under-reported due to diagnostic challenges including the nonspecific radiographic features, lack of diagnostic markers, and often asymptomatic nature of the lesions. Methods: We performed detailed examination of 11 CAPNON specimens diagnosed by histopathology, with the help of electron microscopy and immunohistochemistry. Results: Electron microscopy revealed the presence of fibrillary materials consistent with neurofilaments. In addition to some entrapped axons at the periphery of CAPNONs, we discovered that all specimens stained positive for neurofilament-light (NF-L) within the granular amorphous cores, but not neurofilament-phosphorylated (NF-p). CAPNONs also showed variable infiltration of CD8+ T-cells and a decreased ratio of CD4/CD8+ T-cells, suggesting an immune-mediated process in the pathogenesis of CAPNON. Conclusion: NF-L and CD4/CD8 immunostains may serve as diagnostic markers for CAPNON and shed light on its pathogenesis.
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