Influence of three different anesthesia protocols on aged rat brain: a resting-state functional magnetic resonance imaging study

异氟醚 功能磁共振成像 麻醉 磁共振成像 医学 方差分析 静息状态功能磁共振成像 右美托咪定 事后 默认模式网络 神经科学 内科学 心理学 镇静 放射科
作者
Yang Liu,Huiqun Fu,Yan Wu,Zunshu Du,Bo-Ran Li,Xin Gao,Guanwen Lin,Shuyi Yang,Tianlong Wang
出处
期刊:Chinese Medical Journal [Lippincott Williams & Wilkins]
卷期号:134 (3): 344-352 被引量:3
标识
DOI:10.1097/cm9.0000000000001126
摘要

Abstract Background Resting-state functional magnetic resonance imaging (rs-fMRI) is a promising method for the study of brain function. Typically, rs-fMRI is performed on anesthetized animals. Although different functional connectivity (FC) in various anesthetics on whole brain have been studied, few studies have focused on different FC in the aged brain. Here, we measured FC under three commonly used anesthesia methods and analyzed data to determine if the FC in whole brain analysis were similar among groups. Methods Twenty-four male aged Wistar rats were randomly divided into three groups ( n = 8 in each group). Anesthesia was performed under either isoflurane (ISO), combined ISO + dexmedetomidine (DEX) or α-chloralose (AC) according to the groups. Data of rs-fMRI was analyzed by FC in a voxel-wise way. Differences in the FC maps between the groups were analyzed by one-way analysis of variance and post hoc two-sample t tests. Results Compared with ISO + DEX anesthesia, ISO anesthesia caused increased FC in posterior brain and decreased FC in the middle brain of the aged rat. AC anesthesia caused global suppression as no increase in FC was observed. Conclusion ISO could be used as a substitute for ISO + DEX in rat default mode network studies if the left temporal association cortex is not considered important.
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