Body constitution of traditional Chinese medicine caused a significant effect on depression in adult women

and purpose: Depression is a common mental disorder and reduces quality of life. As traditional Chinese medicine constitution (TCMC) has become an increasingly popular complementary and alternative approach for early detection and treatment of disease, this study investigated the relationship of female-related factors and constitution with depression. This cross-sectional study included 1423 women from the Taiwan Biobank. A questionnaire of 44 items was used covering a variety of factors and the Body Constitution Questionnaire. The constitution types were divided into Yang-deficiency, Yin-deficiency, and Phlegm stasis. Yang (p = 0.022) or Yin (p = 0.017) deficiencies, being single (p = 0.027–0.033), previous use of women's health supplements (p = 0.005–0.008), and smoking (p = 0.033–0.036) were associated with a higher risk of depression. Integration of TCMC with Western medicine may be an alternative option towards depression prevention and alleviation.