溶解
粉末衍射
无定形固体
肺表面活性物质
溶解度
扫描电子显微镜
材料科学
水溶液
溶解试验
溶剂
胶束
化学工程
核化学
色谱法
化学
结晶学
物理化学
有机化学
生物制药分类系统
复合材料
工程类
作者
Ziyue Xi,Wei Zhang,Zisen Gao,Luyao Xie,Lu Chen,Mingshu Cui,Yanru Xi,Lu Xu
标识
DOI:10.1016/j.powtec.2019.10.095
摘要
In this study, the abilities of hydroxypropyl methylcellulose (HPMC) and methylcellulose (MC) as nonionic surfactants to improve the dissolution rate of carvedilol solid dispersions (CAR SDs) with Kollicoat IR as a carrier were clearly demonstrated. CAR SDs were prepared using the solvent evaporation method, and their physicochemical properties were characterized by scanning electron microscopy (SEM) and Powder X-Ray diffraction (PXRD). The results suggested that CAR in SDs existed in an amorphous form. In vitro dissolution experiments and molecular docking (MD) simulations were conducted to confirm the storage stability of CAR SDs. In order to study the mechanism of solubilization ability, molar solubilization ratio (MSR) and micelle-water partition coefficient (Kmic) were calculated. The results showed that the MSR and lg Kmic values of MC/Kollicoat IR 1:3 were around 30 fold higher than the single surfactant. Above all, HPMC and MC have great potentials to improve the dissolution characteristics of CAR-Kollicoat IR SDs.
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