仆从
纳米孔测序
纳米孔
计算生物学
DNA测序
表观遗传学
计算机科学
精密医学
基因组学
生物
数据科学
纳米技术
基因组
遗传学
基因
材料科学
作者
Crescenzio Francesco Minervini,Cosimo Cumbo,Paola Orsini,Luisa Anelli,Antonella Zagaria,Giorgina Specchia,Francesco Albano
标识
DOI:10.3389/fgene.2020.00076
摘要
The molecular pathogenesis of hematological diseases is often driven by genetic and epigenetic alterations. Next-generation sequencing has considerably increased our genomic knowledge of these disorders becoming ever more widespread in clinical practice. In 2012 Oxford Nanopore Technologies (ONT) released the MinION, the first long-read nanopore-based sequencer, overcoming the main limits of short-reads sequences generation. In the last years, several nanopore sequencing approaches have been performed in various "-omic" sciences; this review focuses on the challenge to introduce ONT devices in the hematological field, showing advantages, disadvantages and future perspectives of this technology in the precision medicine era.
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