去唾液酸糖蛋白受体
细胞生物学
溶酶体
细胞外
生物
受体
自噬
化学
生物化学
肝细胞
酶
体外
细胞凋亡
标识
DOI：10.1038/s41589-021-00835-1
摘要
LYTACs induce selective degradation of extracellular proteins by recruiting them to cellular receptors that mediate delivery to the lysosome. Recent development of GalNAc-LYTACs and MoDE-As targeting the liver-specific ASGPR enables cell-type-restricted lysosomal protein degradation and reveals new LYTAC design principles.
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