Cervical adenocarcinoma in situ during pregnancy and subsequent fertility‐sparing therapy challenge

Abstract Objective Adenocarcinoma in situ (AIS) of the cervix is a premalignant lesion, and a precursor of invasive disease. It is less frequent than its squamous counterpart. During pregnancy, AIS is a scarcely described scenario, whose diagnosis barely differs from non‐pregnant patients. Its management is challenging with hysterectomy being the definitive treatment. However, its high incidence in young patients makes fertility‐sparing management an approachable option for selected patients. The objective of this study is twofold. Firstly, we describe a case of a patient with AIS during pregnancy and the postpartum period. Secondly, the available literature is reviewed. Methods Retrospective medical record review of a single case and a medical literature search in Pubmed of AIS cases in pregnant women. Results A 31‐year‐old woman with cervical AIS diagnosed during pregnancy underwent serial fertility‐sparing surgeries including a loop electrosurgical excision procedure and endocervical curettage during the second trimester, and a re‐conization and a simple traquelectomy during the postpartum period, until negative margins were achieved. Upon reviewing the literature from 1965 to 2020, 23 other cases were found. Conclusion Surgical management of cervical AIS during pregnancy is a safe procedure. Subsequent conservative surgeries imply a real challenge to preserve fertility.