Differentiating neurodegenerative parkinsonian syndromes using vestibular evoked myogenic potentials and balance assessment

前庭诱发肌源性电位 平衡(能力) 前庭系统 神经科学 物理医学与康复 医学 心理学 听力学
作者
Dietrich Klunk,Timo B. Woost,Christopher Fricke,Joseph Claßen,David Weise
出处
期刊:Clinical Neurophysiology [Elsevier]
卷期号:132 (11): 2808-2819 被引量:3
标识
DOI:10.1016/j.clinph.2021.08.012
摘要

Vestibular evoked myogenic potentials (VEMP) were investigated to differentiate between parkinsonian syndromes. We correlated balance and VEMP parameters to investigate the VEMP brainstem circuits as possible origin for postural instability. We assessed clinical status, ocular and cervical VEMP (oVEMP, cVEMP) and conducted a balance assessment (posturography, Activities-specific Balance Confidence Scale, Berg Balance Scale, modified Barthel Index) in 76 subjects: 30 with Parkinson’s disease (PD), 16 with atypical parkinsonism (AP) and 30 healthy controls. VEMP were elicited by using a mini-shaker on the forehead. Patients with PD had a prolonged oVEMP n10 in comparison to controls and prolonged p15 compared to controls and AP. Patients with AP showed reduced oVEMP amplitudes compared to PD and controls. CVEMP did not differ between groups. Postural impairment was higher in AP compared to controls and PD, particularly in the rating scales. No correlations between VEMP and posturography were found. A support vector machine classifier was able to automatically classify controls and patient subgroups with moderate to good accuracy based on oVEMP latencies and balance questionnaires. Both oVEMP and posturography, but not cVEMP, may be differentially affected in PD and AP. We did not find evidence that impairment of the cVEMP or oVEMP pathways is directly related to postural impairment. OVEMP and balance assessment could be implemented in the differential diagnostic work-up of parkinsonian syndromes.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
2秒前
3秒前
3秒前
FYm发布了新的文献求助10
3秒前
cl完成签到,获得积分10
3秒前
3秒前
4秒前
ZXT完成签到,获得积分10
4秒前
韩十四完成签到,获得积分10
4秒前
4秒前
大模型应助NL采纳,获得10
5秒前
美满向薇发布了新的文献求助10
5秒前
科研小肖完成签到,获得积分10
5秒前
5秒前
栾小鱼完成签到 ,获得积分10
6秒前
善学以致用应助StandardR采纳,获得10
6秒前
果粒橙爱学习完成签到,获得积分10
6秒前
Wcy发布了新的文献求助10
6秒前
科科发布了新的文献求助10
7秒前
7秒前
7秒前
7秒前
8秒前
8秒前
虫不知应助Joy采纳,获得10
9秒前
344061512发布了新的文献求助10
9秒前
9秒前
多边棱发布了新的文献求助10
10秒前
Eddie Joe发布了新的文献求助10
10秒前
细心弱给细心弱的求助进行了留言
11秒前
lyingwake完成签到,获得积分10
11秒前
可爱的函函应助FYm采纳,获得10
11秒前
chen完成签到 ,获得积分20
12秒前
兴奋的溪灵完成签到,获得积分20
12秒前
游离发布了新的文献求助10
13秒前
梅豪发布了新的文献求助10
13秒前
13秒前
正直凌文完成签到 ,获得积分10
13秒前
tfldog发布了新的文献求助10
13秒前
高分求助中
Handbook of Fuel Cells, 6 Volume Set 1666
Floxuridine; Third Edition 1000
Tracking and Data Fusion: A Handbook of Algorithms 1000
Sustainable Land Management: Strategies to Cope with the Marginalisation of Agriculture 800
消化器内視鏡関連の偶発症に関する第7回全国調査報告2019〜2021年までの3年間 500
One Man Talking: Selected Essays of Shao Xunmei, 1929–1939 500
Framing China: Media Images and Political Debates in Britain, the USA and Switzerland, 1900-1950 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 内科学 物理 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 冶金 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 2861134
求助须知:如何正确求助?哪些是违规求助? 2466480
关于积分的说明 6686911
捐赠科研通 2157612
什么是DOI,文献DOI怎么找? 1146272
版权声明 585087
科研通“疑难数据库(出版商)”最低求助积分说明 563193