金黄色葡萄球菌
脂质体
抗菌剂
药物输送
医学
抗生素
耐甲氧西林金黄色葡萄球菌
输送系统
抗感染药
微生物学
药理学
生物
纳米技术
细菌
材料科学
遗传学
作者
Joshua C. Nwabuife,Amit Pant,Thirumala Govender
标识
DOI:10.1016/j.addr.2021.113861
摘要
Liposomal delivery systems have been widely explored for targeting superbugs such as S. aureus and MRSA, overcoming antimicrobial resistance associated with conventional dosage forms. They have the significant advantage of delivering hydrophilic and lipophilic antimicrobial agents, either singularly as monotherapy or in combination as combination therapy, due to their bilayers with action-site-specificity, resulting in improved targeting compared to conventional dosage forms. Herein, we present an extensive and critical review of the different liposomal delivery systems employed in the past two decades for the delivery of both antibiotics of different classes and non-antibiotic antibacterial agents, as monotherapy and combination therapy to eradicate infections caused by S. aureus and MRSA. The review also identifies future research and strategies potentiating the applications of liposomal delivery systems against S. aureus and MRSA. This review confirms the potential application of liposomal delivery systems for effective delivery and specific targeting of S. aureus and MRSA infections.
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