The α2-Plasmin Inhibitor-Plasmin Complex is a Potential Biomarker of Venous Thromboembolism in Orthopedic Trauma Patients

静脉血栓栓塞 骨科手术 医学 生物标志物 骨科创伤 纤溶酶 内科学 血栓形成 外科 化学 生物化学
作者
Xiaoqian Guo,Haiying Tao,Di Li,Yan Li
出处
期刊:Clinical Laboratory [Clinical Laboratory Publications]
卷期号:67 (04/2021) 被引量:3
标识
DOI:10.7754/clin.lab.2020.200856
摘要

BACKGROUND Venous thromboembolism (VTE) is a common complication in orthopedic trauma patients. Accurate prediction of individual thrombosis risk is important in determining whether prophylactic treatment with anticoagulants is necessary. In this study, we screened for biomarkers that could be used as predictors of VTE risk and evaluated their efficacy and benefit in treating orthopedic traumatic patients. METHODS A total of 683 patients with orthopedic trauma were consecutively enrolled between January 2017 and June 2018 at Renmin Hospital of Wuhan University. Demographic and clinical information was collected, and VTE risk was assessed using the Caprini risk assessment score. The concentrations of PIC, coagulation parameters and other routine biochemical markers were quantified. The Mann-Whitney U test was used to identify potential biomarkers which were significantly different between patients who developed VTE and those who did not. Correlation between individual parameters was assessed using Pearson's correlation. A nomogram model was constructed to predict VTE risk using a combination of biomarkers, and a decision curve analysis was performed to assess the net benefit of using each biomarker. RESULTS Patients with VTE had significantly higher levels of PIC (p = 0.037) and DD (p = 0.042) than those without, even after adjusting for confounding factors. PIC and DD levels increased in a stepwise fashion with increasing VTE risk and were the markers most strongly associated with Caprini score (PIC, r = 0.408; DD, r = 0.474; p < 0.001). In decision curve analysis, PIC levels provided greater net benefit than the Caprini score or DD level across patients with various bleeding risks. CONCLUSIONS Plasma PIC levels are a useful biomarker of VTE risk and can be used to determine whether pharmaco-prophylaxis is needed in orthopedic trauma patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
QQ发布了新的文献求助10
刚刚
优雅泡芙发布了新的文献求助20
1秒前
zj发布了新的文献求助10
1秒前
飞云发布了新的文献求助10
1秒前
满意花生发布了新的文献求助10
1秒前
汉堡包应助落寞冬云采纳,获得10
2秒前
2秒前
陈先生完成签到,获得积分10
2秒前
善良的猪咪完成签到,获得积分10
2秒前
2秒前
whj发布了新的文献求助10
2秒前
LIUqiangAAA完成签到 ,获得积分10
3秒前
所所应助知性的囧采纳,获得10
4秒前
enndyou发布了新的文献求助10
4秒前
传奇3应助NIUB采纳,获得10
4秒前
123完成签到,获得积分20
6秒前
汉堡包应助哈桑士采纳,获得10
6秒前
问夏完成签到,获得积分10
6秒前
les3发布了新的文献求助10
7秒前
a123发布了新的文献求助10
7秒前
8秒前
科研机器完成签到,获得积分10
8秒前
轻松盼雁完成签到,获得积分10
9秒前
9秒前
9秒前
Akim应助帅帅采纳,获得10
9秒前
难难难完成签到,获得积分10
9秒前
小二郎应助不安的秋白采纳,获得10
10秒前
10秒前
10秒前
ddz发布了新的文献求助10
10秒前
11秒前
苹果的苹完成签到,获得积分10
11秒前
11秒前
hahaha发布了新的文献求助10
12秒前
12秒前
Pamburger完成签到,获得积分10
12秒前
13秒前
知性的囧完成签到,获得积分20
14秒前
14秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974856
求助须知:如何正确求助?哪些是违规求助? 3519400
关于积分的说明 11198085
捐赠科研通 3255563
什么是DOI,文献DOI怎么找? 1797860
邀请新用户注册赠送积分活动 877208
科研通“疑难数据库(出版商)”最低求助积分说明 806219