Synthesis of 2-aminobenzofurans via base-mediated [3 + 2] annulation of N-phenoxy amides with gem-difluoroalkenes

Efficient metal-free [3 + 2] annulation of N-phenoxy amides with gem-difluoroalkenes has been realized for the assembly of 2-aminobenzofuran derivatives with potent cytotoxicity against cancer cell lines and application potential for DELs.