发酵
肠道菌群
丁酸盐
拟杆菌
丙酸盐
双歧杆菌
瘤胃球菌
细菌
化学
普雷沃菌属
微生物代谢
厚壁菌
微生物群
生物
食品科学
微生物学
生物化学
失调
益生元
某种肠道细菌
拟杆菌
乳酸菌
遗传学
作者
Lin Pan,X. K. Ai,Tianyu Fu,Li Ren,Qingsen Shang,Guoyun Li,Guangli Yu
标识
DOI:10.1016/j.carbpol.2021.118313
摘要
Hyaluronan (HA) has been widely used as a dietary supplement which can be degraded by gut microbiota. However, the interactions between HA and gut microbiota have not been fully characterized. Here, using an in vitro system, we found that HA is readily fermented by human gut microbiota but with differing fermentative activities among individuals. HA-fermentation boosted Bacteroides spp., Bifidobacterium spp., Dialister spp., Faecalibacterium spp. and produced a significant amount of acetate, propionate and butyrate. Fermentation products profiling indicated that HA could be degraded into unsaturated even-numbered and saturated odd-numbered oligosaccharides. Further, polysaccharide lyases (PLs) and glycoside hydrolases (GHs) including GH88, PL8, PL29, PL35 and PL33 were identified from B. ovatus E3, which can help to explain the structure of the fermentation products. Collectively, our study sheds new light into the metabolism of HA and forms the basis for understanding the bioavailability of HA from a gut microbiota perspective.
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