神经科学
τ蛋白
疾病
Tau病理学
陶氏病
微管
药物靶点
神经退行性变
药物发现
阿尔茨海默病
细胞生物学
医学
生物
药理学
生物信息学
内科学
作者
Jangampalli Adi Pradeepkiran,P. Hemachandra Reddy
标识
DOI:10.1016/j.bbadis.2021.166162
摘要
Tau is a microtubule-stabilizing protein that plays an important role in the formation of axonal microtubules in neurons. Phosphorylated tau (p-Tau) has received great attention in the field of Alzheimer's disease (AD) as a potential therapeutic target due to its involvement with synaptic damage and neuronal dysfunction. Mounting evidence suggests that amyloid beta (Aβ)-targeted clinical trials continuously failed; therefore, it is important to consider alternative therapeutic strategies such as p-tau-PROTACs targeted small molecules for AD and other tauopathies. The present article describes the characteristics of tau biology, structure, and function in both healthy and pathological states in AD. It also explains data from studies that have identified the involvement of p-tau in neuronal damage and synaptic and cognitive functions in AD. Current article also covers several aspects, including small molecule inhibitors, and the development of p-tau-PROTACs targeted drug molecules to treat patients with AD and other tauopathies.
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