Pre-exercise blood glucose affects glycemic variation of aerobic exercise in patients with type 2 diabetes treated with continuous subcutaneous insulin infusion

医学 血糖性 有氧运动 2型糖尿病 内科学 糖尿病 连续血糖监测 胰岛素 曲线下面积 内分泌学
作者
Yun Hu,Danfeng Zhang,Lu Dai,Zheng Li,Huiqin Li,Feng-fei Li,Bing-li Liu,Xiaojuan Sun,Lei Ye,Ke He,Jianhua Ma
出处
期刊:Diabetes Research and Clinical Practice [Elsevier BV]
卷期号:141: 98-105 被引量:9
标识
DOI:10.1016/j.diabres.2018.04.043
摘要

Abstract Aims Considering the insulin sensitivity may increase by exercise particularly in patients with type 2 diabetes (T2D), glycemic variation during exercise needs to be studied when the patients are treated with insulin. This study aimed to explore the influence factors of the efficacy and safety of aerobic exercise in patients with T2D treated with Continuous Subcutaneous Insulin Infusion (CSII). Methods A total of 267 patients with T2D, treated with CSII, were included. Glycemic variations were assessed by continuous glucose monitoring (CGM). Patients were asked to complete 30 min aerobic exercise for at least one time during CGM. The patients were divided into effective and ineffective group by incremental glucose area under curve from 0 to 60 min after exercise (AUC0-60 min). Results The patients completed a total of 776 times of aerobic exercises. Blood glucose decreased fastest in the first 60 min of exercise. Pre-exercise blood glucose (PEBG) was negatively correlated with AUC0-60 min (standardized β = −0.386, P  Conclusions PEBG is positively correlated with efficacy of aerobic exercise. Aerobic exercise will not worsen hyperglycemia when the PEBG > 16.7 mmol/L. Post-dinner exercise decreases the blood glucose better than other periods of the day. Clinical trials registration: ChiCTR-ONC-17010400 , www.chictr.org.cn
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