Abstract Globalization of food trade in agricultural commodities is in some senses the antithesis of key concepts of sustainable agriculture. Global trade in food products distances the depletion of resources and environmental impacts of food production from the economic and social processes that drive consumption and increases the global risks from introduction of species that become pests. However, both supply and market value chains have emerged as major sub-systems in the larger global agro-food trade system that exert enormous importance over the potential for change in agricultural production at the farm level. This special issue presents studies of seven value chains that exhibit the breadth of research about value chains and their potential contributions to sustainable agriculture. They address value chains at different scales and dealing in various products. These studies contribute to the body of knowledge with a focus on lesser researched regions and products. Most important, they demonstrate the potential for value chains to enhance agricultural sustainability for rural populations and reduce food insecurity and inequities.