Synthesis of (E,E,E)-(1,2,3,4-13C4)-Geranylgeraniol

A synthesis of (E,E,E)-(1,2,3,4-13C4)-geranylgeraniol (2‘) (5 steps, ≥ 30% overall yield) is described starting from farnesol (3). The synthesis is based on the Sum/Weiler protocol, which was found to be superior after investigating two different routes in the non-labelled series.