亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Corticosterone Signaling and a Lateral Habenula–Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model

被盖腹侧区 腹侧苍白球 神经科学 麝香醇 皮质酮 人口 生物 心理学 内分泌学 内科学 医学 多巴胺能 兴奋剂 中枢神经系统 多巴胺 基底神经节 激素 苍白球 受体 环境卫生
作者
Yujie Guo,Xun Tang,Jichuan Zhang,Sen Jin,Jinnan Li,Lufeng Ding,Keming Zhang,Chao‐Yu Yang,Hua Zhou,Xiaobin He,Fuqiang Xu,Guo‐Qiang Bi,Lin Xu,Pak-Ming Lau
出处
期刊:The Journal of Neuroscience [Society for Neuroscience]
卷期号:38 (23): 5251-5266 被引量:7
标识
DOI:10.1523/jneurosci.2540-17.2018
摘要

Self-injurious behavior (SIB) is commonly observed in patients with neuropsychiatric disorders, as well as in nonclinical populations with stress-related mental-health problems. However, the exact circuitry mechanisms underlying SIB have remained poorly understood. Here, with bilateral injection of muscimol into the entopeduncular nucleus (EP), we established a rat model of SIB. Following the muscimol injection, the male rats exhibited in a dose-dependent manner stereotypic self-biting behavior that lasted for hours and often resulted in wounds of various severities. The SIB was associated with an elevated level of serum corticosterone and could be exacerbated by enhancing the corticosterone signaling and, conversely, alleviated by inhibiting the corticosterone signaling. Activity mapping using c-fos immunostaining, combined with connectivity mapping using herpes simplex virus-based anterograde tracing from the EP and pseudorabies virus-based retrograde tracing from the masseter muscle, revealed the potential involvement of many brain areas in SIB. In particular, the lateral habenula (LHb) and the ventral tegmental area (VTA), the two connected brain areas involved in stress response and reward processing, showed a significant increase in neuronal activation during SIB. Furthermore, suppressing the LHb activity or modulating the GABAergic transmission in the VTA could significantly reduce the occurrence of SIB. These results demonstrate the importance of stress hormone signaling and the LHb–VTA circuit in modulating SIB resulting from EP malfunction, and suggest potential targets for therapeutic intervention of SIB and related disorders. SIGNIFICANCE STATEMENT Self-injurious behavior (SIB) occurs in ∼4% of the general population, with substantially higher occurrence among adolescents and patients of neuropsychiatric disorders. Stress has been linked to the occurrence of SIB, yet the underlying mechanisms have remained unclear. Using a rat model of SIB induced by disruption of activity in the entopeduncular nucleus (EP), we found that the behavior is regulated by stress and linked to corticosterone signaling. Viral tracing and c-fos immunostaining revealed the involvement of various subcortical areas, especially the EP–lateral habenula (LHb)–ventral tegmental area (VTA) circuit, in SIB. Furthermore, regulating activity in the LHb or the VTA alleviates SIB. These results may have implications in the development of new strategies for treating SIB.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
lawrenceip0926完成签到,获得积分10
刚刚
刚刚
SCT完成签到,获得积分10
2秒前
Joven发布了新的文献求助10
6秒前
Joven完成签到,获得积分20
13秒前
在水一方完成签到 ,获得积分0
21秒前
22秒前
Jasper应助小尾巴采纳,获得10
24秒前
26秒前
科研通AI2S应助科研通管家采纳,获得10
26秒前
26秒前
26秒前
惠民发布了新的文献求助10
27秒前
28秒前
飞翔的发布了新的文献求助10
31秒前
58秒前
柔弱成危发布了新的文献求助10
1分钟前
科研猫头鹰完成签到,获得积分10
1分钟前
不安的裘完成签到 ,获得积分10
1分钟前
Lucas应助morena采纳,获得10
1分钟前
大史完成签到 ,获得积分10
1分钟前
1分钟前
wyb发布了新的文献求助10
1分钟前
橙橙完成签到,获得积分10
1分钟前
千羽飞完成签到,获得积分10
1分钟前
2分钟前
2分钟前
2分钟前
2分钟前
Shaangueuropa发布了新的文献求助30
2分钟前
飞翔的发布了新的文献求助10
2分钟前
隐形曼青应助江上烟采纳,获得10
2分钟前
Shaangueuropa完成签到,获得积分10
2分钟前
Billy应助科研通管家采纳,获得10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
酸奶应助科研通管家采纳,获得10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
2分钟前
2分钟前
2分钟前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Free Will in the Flesh 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3081568
求助须知:如何正确求助?哪些是违规求助? 2734319
关于积分的说明 7532599
捐赠科研通 2383865
什么是DOI,文献DOI怎么找? 1264044
科研通“疑难数据库(出版商)”最低求助积分说明 612506
版权声明 597577