单核吞噬细胞系统
活性氧
脾脏
吞噬细胞
单核细胞
再灌注损伤
缺血
药理学
促炎细胞因子
巨噬细胞
抗氧化剂
炎症
材料科学
免疫学
医学
吞噬作用
生物化学
化学
内科学
体外
作者
Dalong Ni,Hao Wei,Weiyu Chen,Qunqun Bao,Zachary T. Rosenkrans,Todd E. Barnhart,Carolina A. Ferreira,Yanpu Wang,Heliang Yao,Tuanwei Sun,Dawei Jiang,Shiyong Li,Tianye Cao,Zhaofei Liu,Jonathan W. Engle,Ping Hu,Xiaoli Lan,Weibo Cai
标识
DOI:10.1002/adma.201902956
摘要
Abstract The mononuclear phagocyte system (MPS, e.g., liver, spleen) is often treated as a “blackbox” by nanoresearchers in translating nanomedicines. Often, most of the injected nanomaterials are sequestered by the MPS, preventing their delivery to the desired disease areas. Here, this imperfection is exploited by applying nano‐antioxidants with preferential liver uptake to directly prevent hepatic ischemia‐reperfusion injury (IRI), which is a reactive oxygen species (ROS)‐related disease. Ceria nanoparticles (NPs) are selected as a representative nano‐antioxidant and the detailed mechanism of preventing IRI is investigated. It is found that ceria NPs effectively alleviate the clinical symptoms of hepatic IRI by scavenging ROS, inhibiting activation of Kupffer cells and monocyte/macrophage cells. The released pro‐inflammatory cytokines are then significantly reduced and the recruitment and infiltration of neutrophils are minimized, which suppress subsequent inflammatory reaction involved in the liver. The protective effect of nano‐antioxidants against hepatic IRI in living animals and the revealed mechanism herein suggests their future use for the treatment of hepatic IRI in the clinic.
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