Dehydrative Cross‐Coupling and Related Reactions between Alcohols (C−OH) and P(O)−H Compounds for C−P Bond Formation

Abstract In recent decades, reactions of inexpensive and abundantly available alcohols (C−OH) with nucleophilic P(O)−H compounds, leading to the construction of C−P bonds, have emerged as one of the most efficient strategies as it is an atom‐economical and environmental benign approach with water as the only by‐product. Various organophosphorus compounds bearing C( sp 3 )−P, C(aryl)−P and C(alkenyl)−P bonds have been achieved via this direct dehydrative cross‐couplings under Brønsted or Lewis acid catalysis. This review article aims to summarize the recent advances in such dehydrative and related C−P bond forming strategies, to briefly discuss the reaction mechanisms and challenges, and to outline synthetic opportunities that are still open. magnified image