霍乱弧菌
VI型分泌系统
水平基因转移
细菌
毒力
微生物学
基因
生物
分泌物
调节器
DNA
遗传学
基因表达调控
基因组
生物化学
作者
Sandrine Borgeaud,Lisa C. Metzger,Tiziana Scrignari,Melanie Blokesch
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2015-01-02
卷期号:347 (6217): 63-67
被引量:352
标识
DOI:10.1126/science.1260064
摘要
Killing, sex, and gene swaps in bacteria The bacterial type VI secretion system (T6SS) is used by bacteria to inject toxins into neighboring cells to eliminate competition. This molecular machine is thus considered to be a mechanism by which bacteria can exert social control in complex microbial communities. Borgeaud et al. have discovered that in Vibrio cholerae , T6SS genes are co-regulated with genes involved in DNA uptake. Hence, T6SS-dependent killing of other bacteria is directed at neighboring cells, which release their DNA to be taken up by the killer, which can then integrate valuable genes and rapidly evolve, leading to antibiotic resistance or virulence. Science , this issue p. 63
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