First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multigene Cluster

ChemBioChemVolume 11, Issue 11 p. 1508-1512 Communication First Heterologous Reconstruction of a Complete Functional Fungal Biosynthetic Multigene Cluster Mary N. Heneghan Dr., Mary N. Heneghan Dr. [email protected] School of Biological Sciences, Woodland Road, Bristol BS8 1UG (UK)Search for more papers by this authorAhmed A. Yakasai, Ahmed A. Yakasai School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK), Fax: (+44) 117-929-8611Search for more papers by this authorLaura M. Halo Dr., Laura M. Halo Dr. School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK), Fax: (+44) 117-929-8611Search for more papers by this authorZhongshu Song Dr., Zhongshu Song Dr. School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK), Fax: (+44) 117-929-8611Search for more papers by this authorAndrew M. Bailey Dr., Andrew M. Bailey Dr. School of Biological Sciences, Woodland Road, Bristol BS8 1UG (UK)Search for more papers by this authorThomas J. Simpson Prof., Thomas J. Simpson Prof. School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK), Fax: (+44) 117-929-8611Search for more papers by this authorRussell J. Cox Prof., Russell J. Cox Prof. [email protected] School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK), Fax: (+44) 117-929-8611Search for more papers by this authorColin M. Lazarus Dr., Colin M. Lazarus Dr. [email protected] School of Biological Sciences, Woodland Road, Bristol BS8 1UG (UK)Search for more papers by this author Mary N. Heneghan Dr., Mary N. Heneghan Dr. [email protected] School of Biological Sciences, Woodland Road, Bristol BS8 1UG (UK)Search for more papers by this authorAhmed A. Yakasai, Ahmed A. Yakasai School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK), Fax: (+44) 117-929-8611Search for more papers by this authorLaura M. Halo Dr., Laura M. Halo Dr. School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK), Fax: (+44) 117-929-8611Search for more papers by this authorZhongshu Song Dr., Zhongshu Song Dr. School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK), Fax: (+44) 117-929-8611Search for more papers by this authorAndrew M. Bailey Dr., Andrew M. Bailey Dr. School of Biological Sciences, Woodland Road, Bristol BS8 1UG (UK)Search for more papers by this authorThomas J. Simpson Prof., Thomas J. Simpson Prof. School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK), Fax: (+44) 117-929-8611Search for more papers by this authorRussell J. Cox Prof., Russell J. Cox Prof. [email protected] School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS (UK), Fax: (+44) 117-929-8611Search for more papers by this authorColin M. Lazarus Dr., Colin M. Lazarus Dr. [email protected] School of Biological Sciences, Woodland Road, Bristol BS8 1UG (UK)Search for more papers by this author First published: 19 July 2010 https://doi.org/10.1002/cbic.201000259Citations: 88Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Graphical Abstract Fungal chemical factory: Controlled expression of the complete tenellin biosynthetic pathway from Beauveria bassiana was achieved in the heterologous host Aspergillus oryzae by replacing the promoters of all four of its component genes with the A. oryzae amyB promoter; this produces tenellin at over five times the concentration of the native host. Citing Literature Volume11, Issue11July 26, 2010Pages 1508-1512 RelatedInformation