血管生成
车站3
调解人
STAT蛋白
转录因子
新生血管
信号转导
抄写(语言学)
生物
细胞生物学
激活剂(遗传学)
癌症研究
癌变
遗传学
受体
基因
哲学
语言学
作者
Zhong Chen,Zhongchao Han
摘要
Abstract Angiogenesis, the formation of new blood vessels from the pre‐existing vasculature, is a complex multistage process regulated by a number of signal transduction pathways. Accumulating evidence suggests that signal transducer and activator of transcription (STATs), mainly STAT3, play an important role in angiogenesis under both physiological and pathological conditions in addition to cell survival, proliferation, differentiation, and oncogenesis. STAT3, as a critical multifunctional mediator, regulates many aspects of angiogenesis at the transcriptional level. This review will highlight the pivotal role of STAT3 in well‐studied tumorous angiogenesis and cardiac angiogenesis, and summarize various potential mechanisms utilized by STAT3 to regulate the transcriptional activation of VEGF. © 2007 Wiley Periodicals, Inc. Med Res Rev, 28, No. 2, 185–200, 2008
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