The prognostic value of left ventricular systolic function measured by tissue Doppler imaging in septic shock

医学 感染性休克 多普勒成像 危险系数 心脏病学 内科学 置信区间 前瞻性队列研究 休克(循环) 比例危险模型 心源性休克 射血分数 血流动力学 多普勒效应 心室功能 败血症 血压 心肌梗塞 舒张期
作者
Li Weng,Yongtai Liu,Bin Du,Jianfang Zhou,Xiaoxiao Guo,Jin-Min Peng,Xiaoyun Hu,Shuyang Zhang,Quan Fang,Wen-ling Zhu
出处
期刊:Critical Care [BioMed Central]
卷期号:16 (3): R71-R71 被引量:57
标识
DOI:10.1186/cc11328
摘要

Left ventricular (LV) dysfunction is common in septic shock. Its association with the clinical outcome is still controversial. Tissue Doppler imaging (TDI) is a useful tool to quantify LV function; however, little knowledge is available about the prognostic value of these TDI variables in septic shock. Therefore, we performed this prospective study to determine the role of TDI variables in septic shock.Patients with septic shock in a medical intensive care unit were studied with transthoracic echocardiography with TDI within 24 hours after the onset of septic shock. Baseline clinical, laboratory, and echocardiographic variables were prospectively collected. Independent predictors of 90-day mortality were analyzed with the Cox regression model.During a 20-month period, 61 patients were enrolled in the study. The 90-day mortality rate was 39%; the mean APACHE IV score was 84 (68 to 97). Compared with survivors, nonsurvivors exhibited significantly higher peak systolic velocity measured at the mitral annulus (Sa) (11.0 (9.1 to 12.5) versus 7.8 (5.5 to 9.0) cm/sec; P < 0.0001), lower PaO2/FiO2 (123 (83 to 187) versus 186 (142 to 269) mm Hg; P = 0.002], higher heart rate (120 (90 to 140) versus 103 (90 to 114) beats/min; P = 0.004], and a higher dose of norepinephrine (0.6 (0.2 to 1.0) versus 0.3 (0.2 to 0.5) μg/kg/min; P = 0.007]. In the multivariate analysis, Sa > 9 cm/sec (hazard ratio (HR), 5.559; 95% confidence interval (CI), 2.160 to 14.305; P < 0.0001), dose of norepinephrine (HR, 1.964; 95% CI, 1.338 to 2.883; P = 0.001), and PaO2/FiO2 (HR, 0.992; 95% CI, 0.984 to 0.999; P = 0.031) remain independent predictors of 90-day mortality in septic-shock patients.Our study demonstrated that LV systolic function as determined by TDI, in particular, Sa, might be associated with mortality in patients with septic shock.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
cm发布了新的文献求助10
刚刚
2秒前
2秒前
2秒前
2秒前
2秒前
大力水手完成签到,获得积分0
4秒前
6秒前
cm完成签到,获得积分10
8秒前
酷炫的听枫完成签到 ,获得积分10
9秒前
吱吱吱完成签到 ,获得积分10
10秒前
11秒前
上善若水呦完成签到 ,获得积分10
11秒前
小羡完成签到 ,获得积分10
11秒前
cqwswfl完成签到 ,获得积分20
12秒前
南山无梅落完成签到,获得积分10
13秒前
啵妞完成签到 ,获得积分10
13秒前
上官若男应助qiqi采纳,获得30
15秒前
拼搏的潘子完成签到,获得积分10
16秒前
zsj完成签到,获得积分10
17秒前
dolesy发布了新的文献求助10
18秒前
执着烧鹅完成签到 ,获得积分10
18秒前
哈哈哈完成签到,获得积分10
20秒前
yar应助博修采纳,获得10
22秒前
可爱的函函应助博修采纳,获得10
22秒前
MchemG应助博修采纳,获得10
22秒前
酷波er应助博修采纳,获得10
23秒前
时代更迭完成签到 ,获得积分10
23秒前
24秒前
WGOIST完成签到,获得积分10
25秒前
九九完成签到 ,获得积分10
25秒前
李新宇完成签到 ,获得积分10
26秒前
大橙子发布了新的文献求助10
30秒前
库凯伊完成签到,获得积分10
30秒前
duckspy发布了新的文献求助10
31秒前
CodeCraft应助jenny采纳,获得10
33秒前
lhnsisi完成签到,获得积分10
34秒前
jhlz5879完成签到,获得积分10
35秒前
悦耳曼凝完成签到 ,获得积分10
36秒前
文静的紫萱完成签到,获得积分10
36秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022