Dynamic Strain Ageing (DSA) has reached widespread acceptance since its proposal in the 1940’s as the mechanism behind the Portevin-Le Chatelier effect in ferritic steels. However, it remains an open question as to whether the classical mechanism can be extended to Face-Centred Cubic (FCC) alloys, including nickel-based superalloys, as often implicitly assumed. Given the historical link between serrated flow and loss of ductility in steels, understanding such consequences in superalloys used in key components of a jet engine demands attention. This review compares plastic instabilities in superalloys to those in ferritic steels, including the effects of temperature, strain rate, compositional, microstructural and extrinsic testing parameters on the extent of serrated flow and consequences on mechanical properties. Outstanding issues are discussed in detail, relating both to the lack of a complete experimental argument depicting the origins of serrated flow and different serration ‘Types’, as well as the inability of current predictive models to fully account for multiscale experimental observations. Proposed explanations for plastic instabilities in FCC alloys are discussed, including but not limited to classical DSA, with the aim to guide future experiments to elucidate the origins of serrated flow across length scales and improve key properties such as fatigue life.