淋巴结
背景(考古学)
淋巴系统
基质
生物
病理
淋巴
器官发生
免疫学
医学
免疫组织化学
遗传学
基因
古生物学
作者
Kerim Hoorweg,Tom Cupedo
标识
DOI:10.1016/j.smim.2008.02.003
摘要
In contrast to our understanding of murine lymphoid organogenesis, detailed knowledge on the mechanisms of human lymph node development is virtually lacking. This is mainly due to the obvious difficulties that accompany research using human fetal organs. In this review we will highlight current knowledge on human lymph node and Peyer's patch development and will temporally align observations made in humans with data available from murine studies. In the final paragraphs we will put this knowledge in the context of human malignancies in which interactions between lymphocytes and stroma, resembling those seen in lymphoid organs, are recapitulated.
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