Is the geriatric depression scale a reliable screening tool for depressive symptoms in elderly patients with cognitive impairment?

老人忧郁量表 痴呆 萧条(经济学) 金标准(测试) 接收机工作特性 认知障碍 小型精神状态检查 内科学 医学 心理学 认知 物理疗法 抑郁症状 疾病 精神科 经济 宏观经济学
作者
Hans Debruyne,Michael Van Buggenhout,Nathalie Le Bastard,Marcel Aries,Kurt Audenaert,Peter Paul De Deyn,Sebastiaan Engelborghs
出处
期刊:International Journal of Geriatric Psychiatry [Wiley]
卷期号:24 (6): 556-562 被引量:118
标识
DOI:10.1002/gps.2154
摘要

To determine the reliability of the 30-item Geriatric Depression Scale (GDS-30) for the screening of depressive symptoms in dementia and mild cognitive impairment (MCI) using the Cornell Scale for Depression in Dementia (CSDD) as the 'gold standard'.Diagnosed according to strictly applied clinical diagnostic criteria, patients with MCI (n = 156) and probable Alzheimer's disease (AD) (n = 247) were included. GDS-30, CSDD, Mini Mental State Examination (MMSE) and Global Deterioration Scale were assessed in all patients at inclusion. The AD group was divided in three subgroups: mild AD (MMSE>or=18) (n = 117), moderate AD (MMSE< 18 and >or=10) (n = 89) and severe AD (MMSE<10) (n = 38).In MCI patients, moderate but highly significant correlations were found between GDS-30 and CSDD scores (Pearson: r = 0.565; p < 0.001). In mildly (r = 0.294; p = 0.001), moderately (r = 0.273; p = 0.010) and severely (r = 0.348; p = 0.032) affected AD patients, only weak correlations between GDS-30 and CSDD scores were calculated. ROC curve analysis showed that sensitivity and specificity values of respectively 95% and 67% were achieved when a GDS-30 cut-off score of 8 was applied in MCI patients. In AD patients, too low sensitivity and specificity values did not allow selecting an optimal cut-off score by means of ROC curve analysis.Using the CSDD as 'gold standard', we demonstrated that the GDS-30 is a reliable screening tool for depressive symptoms in MCI but not in AD patients.
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