Cardiovascular Outcomes in Patients With Primary Aldosteronism After Treatment

原发性醛固酮增多症 医学 心脏病学 螺内酯 内科学 血压 醛固酮 原发性高血压 心肌梗塞 优势比 肾上腺切除术 继发性高血压 临床终点 随机对照试验
作者
Cristiana Catena
出处
期刊:Archives of internal medicine [American Medical Association]
卷期号:168 (1): 80-80 被引量:512
标识
DOI:10.1001/archinternmed.2007.33
摘要

Background

Experimental and human studies demonstrate that long-term exposure to elevated aldosterone levels results in cardiac and vascular damage.

Methods

We investigated long-term cardiovascular outcomes in patients with primary aldosteronism after surgical or medical treatment. Fifty-four patients with or without evidence of adrenal adenomas were prospectively followed up for a mean of 7.4 years after treatment with adrenalectomy or spironolactone. Patients with primary aldosteronism were compared with patients with essential hypertension and were treated to reach a blood pressure of less than 140/90 mm Hg. The main outcome measure was a combined cardiovascular end point comprising myocardial infarction, stroke, any type of revascularization procedure, and sustained arrhythmias.

Results

At baseline, the prevalence of cardiovascular events was greater in primary aldosteronism (35%) than in essential hypertension (11%) (odds ratio, 4.61; 95% confidence interval, 2.38-8.95;P < .001), with odds ratios of 4.93, 4.36, and 2.80 for sustained arrhythmias, cerebrovascular events, and coronary heart disease, respectively. Blood pressure during follow-up was comparable in the primary aldosteronism and essential hypertension groups. Ten patients in the primary aldosteronism group and 19 in the essential hypertension group reached the primary end point (P = .85). Cox analysis indicated that older age and longer duration of hypertension were factors independently associated with the cardiovascular end point. Cardiovascular outcome was comparable in patients with aldosteronism treated with adrenalectomy vs aldosterone antagonists (P = .71).

Conclusion

Primary aldosteronism is associated with a cardiovascular complication rate out of proportion to blood pressure levels that benefits substantially from surgical and medical treatment in the long term.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
生椰拿铁不加生椰完成签到 ,获得积分10
1秒前
认真的灵竹完成签到 ,获得积分10
2秒前
Zxx关注了科研通微信公众号
3秒前
3秒前
franca2005完成签到 ,获得积分10
3秒前
本末倒纸完成签到 ,获得积分10
5秒前
wbscz应助星辰采纳,获得10
5秒前
toxikon发布了新的文献求助10
6秒前
7秒前
9秒前
大模型应助剁辣椒蒸鱼头采纳,获得20
9秒前
小北完成签到 ,获得积分10
9秒前
10秒前
高挑的冰露完成签到 ,获得积分10
13秒前
ruochenzu发布了新的文献求助10
13秒前
老李完成签到,获得积分10
13秒前
14秒前
15秒前
tough_cookie完成签到 ,获得积分10
16秒前
彩钢房完成签到,获得积分10
17秒前
MeSs完成签到 ,获得积分10
18秒前
toxikon完成签到,获得积分10
19秒前
一点通完成签到,获得积分10
19秒前
Lei完成签到,获得积分10
20秒前
20秒前
20秒前
常若冰完成签到,获得积分10
20秒前
纯真的元风完成签到,获得积分10
21秒前
哇哈哈哈完成签到,获得积分10
21秒前
清秋1001完成签到 ,获得积分10
22秒前
qq完成签到,获得积分10
23秒前
荒野风发布了新的文献求助10
24秒前
Zxx发布了新的文献求助10
25秒前
26秒前
26秒前
确幸完成签到 ,获得积分10
26秒前
苒苒完成签到,获得积分10
26秒前
27秒前
酷波er应助c123采纳,获得10
27秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038619
求助须知:如何正确求助?哪些是违规求助? 3576294
关于积分的说明 11375058
捐赠科研通 3306084
什么是DOI,文献DOI怎么找? 1819374
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815066