昼夜节律
代谢综合征
疾病
发病机制
生物信息学
神经科学
机制(生物学)
肥胖
医学
睡眠(系统调用)
糖尿病
生物
生理学
内科学
内分泌学
哲学
操作系统
认识论
计算机科学
作者
Eléonore Maury,Kathryn Moynihan Ramsey,Joseph Bass
出处
期刊:Circulation Research
[Ovid Technologies (Wolters Kluwer)]
日期:2010-02-19
卷期号:106 (3): 447-462
被引量:427
标识
DOI:10.1161/circresaha.109.208355
摘要
Abstract : The incidence of the metabolic syndrome represents a spectrum of disorders that continue to increase across the industrialized world. Both genetic and environmental factors contribute to metabolic syndrome and recent evidence has emerged to suggest that alterations in circadian systems and sleep participate in the pathogenesis of the disease. In this review, we highlight studies at the intersection of clinical medicine and experimental genetics that pinpoint how perturbations of the internal clock system, and sleep, constitute risk factors for disorders including obesity, diabetes mellitus, cardiovascular disease, thrombosis and even inflammation. An exciting aspect of the field has been the integration of behavioral and physiological approaches, and the emerging insight into both neural and peripheral tissues in disease pathogenesis. Consideration of the cell and molecular links between disorders of circadian rhythms and sleep with metabolic syndrome has begun to open new opportunities for mechanism-based therapeutics.
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