戊糖苷
美拉德反应
化学
尿
体内
肌酐
生物化学
糖基化
生物
生物技术
受体
作者
Manuel Portero‐Otín,Reinald Pamplona,Marı́a Josep Bellmunt,M Bergua,Ramanakoppa H. Nagaraj,Joan Prat
出处
期刊:Life Sciences
[Elsevier]
日期:1996-12-01
卷期号:60 (4-5): 279-287
被引量:19
标识
DOI:10.1016/s0024-3205(96)00628-5
摘要
The presence of pyrraline, a non-oxidative glucose-derived Maillard reaction product in plasma proteins has been established previously. In this study we have investigated the presence of pyrraline in human urine to determine whether pyrraline-containing proteins are metabolized or selectively retained. Pyrraline was detected by means of HPLC, and its presence was confirmed by UV and electrospray-mass spectrometry. The quantification of pyrraline in urine from healthy individuals showed 1.21 +/- 0.4 micrograms/mg creatinine. In urine from diabetic patients, pyrraline levels varied considerably, although the mean level was higher than in healthy subjects (1.37 +/- 0.6 micrograms/mg creatinine). These data further support the presence of a catabolic pathway for advanced non-oxidative Maillard reaction products in vivo and suggest their role in the pathogenesis of diabetes.
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