利坦西林
依帕匹隆
抗焦虑药
普萘洛尔
高架加迷宫
药理学
刺激
习得的无助感
内分泌学
心理学
内科学
受体拮抗剂
化学
5-羟色胺受体
受体
敌手
医学
血清素
焦虑
发展心理学
精神科
作者
Frederico Guilherme Graeff,Elisabeth Aparecida Audi,Sebastião de Sousa Almeida,Eneida O. Graeff,Maria Helena Leite Hunziker
标识
DOI:10.1016/s0149-7634(05)80074-0
摘要
In order to illustrate the use of animal models in the study of the anxiolytic and antidepressant properties of drugs acting on 5-HT receptors, a series of experiments is described. With electrical stimulation of the midbrain central gray (CG), an aversive area of the brain, the 5-HT-1 receptor antagonist propranolol raised the aversive threshold in a dose-dependent way, following its microinjection into the CG. This antiaversive effect of propranolol, which is similar to that of benzodiazepine anxiolytics, was prevented by microinjection into the same brain site of the 5-HT-2 receptor blocker ritanserin. Ritanserin itself and the 5-HT-1A receptor ligand ipsapirone caused either little or no effect. In another animal model of anxiety, the elevated plus-maze, intra-CG propranolol also caused an anxiolytic-like effect, antagonized by ritanserin, indicating a 5-HT mediation. However, systemically injected isamoltane, a congener of propranolol, was ineffective in the elevated plus-maze, whereas ipsapirone caused an anxiolytic effect. Ritanserin was again inactive. Finally, both ipsapirone as well as another 5-HT-1A receptor ligand BAY R 1531, given IP, reversed the learning deficit resulting from exposure to uncontrollable foot-shocks, an effect characteristic of antidepressant drugs.
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