TLR9型
Toll样受体9
CpG站点
生物
CpG寡核苷酸
免疫系统
细胞生物学
受体
先天免疫系统
信号转导
免疫学
Toll样受体
DNA甲基化
基因
遗传学
基因表达
作者
Daniela Verthelyi,Rainald Zeuner
标识
DOI:10.1016/s1471-4906(03)00243-6
摘要
CpG-containing oligodeoxynucleotides (CpG ODNs) act on Toll-like receptor 9 (TLR9) that is expressed on B cells and plasmacytoid dendritic cells (pDCs) to stimulate the innate immune system, however, different types of CpG ODNs induce distinct responses. Recent papers suggest some CpG ODNs could require a second receptor or cofactor to signal. The different signaling complexes assembled might impact on the affinity with which CpG ODNs signal to TLR9 or activate additional pathways that lead to distinct immune responses.
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