电泳剂
取代基
化学
催化作用
苯
铜
选择性
分子
药物化学
组合化学
反应性(心理学)
有机化学
医学
替代医学
病理
作者
Robert J. Phipps,Matthew J. Gaunt
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2009-03-20
卷期号:323 (5921): 1593-1597
被引量:914
标识
DOI:10.1126/science.1169975
摘要
For over a century, chemical transformations of benzene derivatives have been guided by the high selectivity for electrophilic attack at the ortho/para positions in electron-rich substrates and at the meta position in electron-deficient molecules. We have developed a copper-catalyzed arylation reaction that, in contrast, selectively substitutes phenyl electrophiles at the aromatic carbon-hydrogen sites meta to an amido substituent. This previously elusive class of transformation is applicable to a broad range of aromatic compounds.
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