疲労感や睡眠の問題を自覚している勤労者におけるGABA 含有食品の気分・感情および睡眠の質に与える影響―二重盲検無作為化比較試験―

Objective This study aims to evaluate the improvement effects of orally administrated γ-aminobutyric acid（GABA）on mood status, sleep quality and fatigue in worker. Methods A total of 62 subjects were randomly divided into either the GABA（100 mg╱day） or placebo group. They orally consumed the respective test substance every day for 12 weeks. Perceived mood and quality of sleep were measured by the Profile of Mood States second edition（POMS 2）, Pittsburgh Sleep Quality Index（PSQI）, Athens Insomnia Scale（AIS）, and Visual Analogue Scale for Fatigue（VAS-F）. This study was registered in UMIN-CTR （UMI19308）. Results Compared with the placebo group, the GABA group showed a significant increase the vigor-activity scale measured by POMS 2 at week 6 relative to the baseline（P＝0.045）. Conclusion Oral administration of GABA could enhance positive feelings such as vigor and energy, in subjects who were aware of fatigue and sleep disorders in their daily life.