Animal models of atherosclerosis

载脂蛋白E 低密度脂蛋白受体 基因剔除小鼠 动物模型 PCSK9 心肌梗塞 载脂蛋白B 易损斑块 医学 胆固醇 病理 生物 动脉硬化 生物信息学 内科学 受体 脂蛋白 疾病
作者
Besa Emini Veseli,Paola Perrotta,Gregory R. A. De Meyer,Lynn Roth,Carole Van der Donckt,Wim Martinet,Guido R.Y. De Meyer
出处
期刊:European Journal of Pharmacology [Elsevier BV]
卷期号:816: 3-13 被引量:460
标识
DOI:10.1016/j.ejphar.2017.05.010
摘要

An ideal animal model of atherosclerosis resembles human anatomy and pathophysiology and has the potential to be used in medical and pharmaceutical research to obtain results that can be extrapolated to human medicine. Moreover, it must be easy to acquire, can be maintained at a reasonable cost, is easy to handle and shares the topography of the lesions with humans. In general, animal models of atherosclerosis are based on accelerated plaque formation due to a cholesterol-rich/Western-type diet, manipulation of genes involved in the cholesterol metabolism, and the introduction of additional risk factors for atherosclerosis. Mouse and rabbit models have been mostly used, followed by pigs and non-human primates. Each of these models has its advantages and limitations. The mouse has become the predominant species to study experimental atherosclerosis because of its rapid reproduction, ease of genetic manipulation and its ability to monitor atherogenesis in a reasonable time frame. Both Apolipoprotein E deficient (ApoE-/-) and LDL-receptor (LDLr) knockout mice have been frequently used, but also ApoE/LDLr double-knockout, ApoE3-Leiden and PCSK9-AAV mice are valuable tools in atherosclerosis research. However, a great challenge was the development of a model in which intra-plaque microvessels, haemorrhages, spontaneous atherosclerotic plaque ruptures, myocardial infarction and sudden death occur consistently. These features are present in ApoE-/-Fbn1C1039G+/- mice, which can be used as a validated model in pre-clinical studies to evaluate novel plaque-stabilizing drugs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
充电宝应助NVLEKU采纳,获得10
1秒前
2秒前
2秒前
天天快乐应助zhu采纳,获得10
3秒前
IRer79发布了新的文献求助10
3秒前
量子星尘发布了新的文献求助10
3秒前
麦丰完成签到,获得积分10
3秒前
3秒前
likke完成签到,获得积分20
4秒前
4秒前
FashionBoy应助li采纳,获得10
5秒前
5秒前
SciGPT应助薛定谔的猫采纳,获得10
5秒前
6秒前
6秒前
muming完成签到,获得积分20
7秒前
sanlunainiu发布了新的文献求助10
7秒前
林博研完成签到,获得积分20
7秒前
FashionBoy应助风趣的灵枫采纳,获得10
8秒前
9秒前
yihuiqing发布了新的文献求助10
10秒前
likke发布了新的文献求助10
10秒前
嗝嗝发布了新的文献求助10
10秒前
小兔狸花昕完成签到,获得积分20
11秒前
IRer79完成签到,获得积分10
13秒前
彭于晏应助noah采纳,获得10
13秒前
青年才俊发布了新的文献求助10
13秒前
zhu发布了新的文献求助10
14秒前
波波蛋完成签到,获得积分10
14秒前
15秒前
16秒前
17秒前
maguodrgon发布了新的文献求助10
20秒前
科研通AI5应助shell采纳,获得80
20秒前
波波蛋发布了新的文献求助10
20秒前
21秒前
九鹤完成签到,获得积分10
21秒前
jsy完成签到,获得积分10
21秒前
量子星尘发布了新的文献求助10
22秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
Zeolites: From Fundamentals to Emerging Applications 1500
Architectural Corrosion and Critical Infrastructure 1000
Early Devonian echinoderms from Victoria (Rhombifera, Blastoidea and Ophiocistioidea) 1000
By R. Scott Kretchmar - Practical Philosophy of Sport and Physical Activity - 2nd (second) Edition: 2nd (second) Edition 666
Energy-Size Reduction Relationships In Comminution 500
Principles Of Comminution, I-Size Distribution And Surface Calculations 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 内科学 生物化学 物理 计算机科学 纳米技术 遗传学 基因 复合材料 化学工程 物理化学 病理 催化作用 免疫学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 4941339
求助须知:如何正确求助?哪些是违规求助? 4207390
关于积分的说明 13077624
捐赠科研通 3986257
什么是DOI,文献DOI怎么找? 2182529
邀请新用户注册赠送积分活动 1198125
关于科研通互助平台的介绍 1110387