甲苯唑啉
咪唑啉受体
化学
可乐定
药理学
药品
血红蛋白
医学
生物化学
内分泌学
作者
Hsiao‐Hua Chang,Sandra M. Ewert,R L Nagel
出处
期刊:Molecular Pharmacology
[American Society for Pharmacology and Experimental Therapeutics]
日期:1983-05-01
卷期号:23 (3): 731-734
被引量:8
标识
DOI:10.1016/s0026-895x(25)14347-2
摘要
The drugs tolazoline, clonidine, lofexidine, and fenmetozole were found to inhibit the gelation of hemoglobin S in the order of increasing effectiveness. Only the latter, however, reduced the sickling of red cells significantly and normalized the oxygen affinity of SS blood at 5-10 mM concentrations. Since this level of drug is lower than those reported for many other anti-sickling agents to achieve comparable effects, the 2-imidazoline class of compounds may provide important clues for the development of therapy for sickle cell anemia.
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