化学发光
中性粒细胞
呼吸爆发
P物质
N-甲酰甲硫氨酸亮氨酸苯丙氨酸
脱敏(药物)
氧化磷酸化
医学
新陈代谢
苯丙氨酸
活性氧
生物化学
内分泌学
免疫学
内科学
受体
化学
炎症
氨基酸
神经肽
有机化学
作者
Ingiäld Hafström,Hans Gyllenhammar,J Palmblad,Bo Ringertz
出处
期刊:PubMed
日期:1989-08-01
卷期号:16 (8): 1033-7
被引量:8
摘要
The substance P (SP) fragment SP(7-11) induced chemiluminescence (CL) and aggregation in human neutrophils at high concentrations (greater than or equal to 10 microM), whereas the entire molecule SP(1-11) was less potent and the SP(1-4) fragment was inactive. At these concentrations SP and its fragments also inhibited CL and aggregation evoked by subsequent addition of formyl-methionyl-leucyl-phenylalanine (fMLP), an effect that may depend on desensitization. However, at lower concentrations (1-10 nM) SP was able to prime human neutrophils to enhanced CL and enzyme release stimulated by fMLP. These findings indicate that, in addition to direct activation of CL and aggregation, SP also modulates neutrophil function and can thus amplify the release of potentially cytotoxic substances, a possible mechanism for nervous system involvement in rheumatoid arthritis.
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